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SCIENTIFIC STUDIES

08/01/22

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Our latest scientific  comprehensive overview of the health benefits of the sorghum bicolor supplement,  which has passed the peer-reviewed stage is now online.

This is the strongest by far of the scientific validation of Jobelyn® with its Trifecta benefits and the extra Chemo-preventive props. 

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An Evidence-based Systematic Review of Pleiotropic Potential Health Benefits of Sorghum bicolor Supplement: A Polyphenol-rich Derivative of the Leaf Sheaths of Sorghum Plant

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Below is the link to the preprint copy of the article:

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Polyphenol Rich Nutritional Supplement Derived from the West African Sorghum Bicolor Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects

Link to full article

2016

Sickle Cell Clinical Trials with Jobelyn®

The Short Time Effect of Extract of Sorghum Bicolor (Jobelyn) on the Haematological Parameters of Patients with Sickle Cell Anaemia

Link to full article

National Cancer Institute – Sorghum bicolor & Jobelyn® mention regarding health supplement.

Sorghum bicolor supplement

An herbal-based nutritional supplement containing the leaf sheaths of the plant Sorghum bicolor, with potential antioxidant, anti-inflammatory, chemopreventive and immunomodulating activities. Sorghum bicolor supplement ...

Link to full article

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Sub-acute toxicological effects of Jobelyn® on pregnant albino rats American Institute of Physics

Adebayo, A.H.; Yakubu, O.F.; Egbung, G.E.; Williams, O.I.; Okubena, O. Sub-acute toxicological effects of Jobelyn® on pregnant albino rats American Institute of Physics 2018, 1954:030018 doi.org/10.1063/1.5033398.

 

The West African Sorghum bicolor leaf sheath extract Jobelyn® and its diverse therapeutic potentials.

Okubena, O.; Makanjuola, S.; Ajonuma, L.C.; Dosunmu, A.; Umukoro, S.; Erah, P.O. The West African Sorghum bicolor leaf sheath extract Jobelyn® and its diverse therapeutic potentials. MOJ Drug Design & Development Therapy 2018, 2, 1-10. DOI: 10.15406/mojddt.2018.02.00025.

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Apigenin and apigeninidin isolates from the Sorghum bicolor leaf targets inflammation via cyclooxygenase‐2 and prostaglandin‐E2 blockade.

Makanjuola, S.B.L.; Ogundaini, A.O.; Ajonuma, L.C.; Dosunmu, A. Apigenin and apigeninidin isolates from the Sorghum bicolor leaf targets inflammation via cyclooxygenase‐2 and prostaglandin‐E2 blockade. Clin Transplant. 2018, 21, 1487‐

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The influence of African herbal formular on the haematological parameters of trypanosome infected rats.

Okochi VI, Okpuzor J, Okubena MO, Awoyemi AK. The influence of African herbal formular on the haematological parameters of trypanosome infected rats. J. Biotech. 2003, 2, 312–316.

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Erah, P.O.; Asonye, C.C, Okhamafe, A.O. Response of trypanosoma brucei-induced anaemia to a commercial herbal preparation.

Erah, P.O.; Asonye, C.C, Okhamafe, A.O. Response of trypanosoma brucei-induced anaemia to a commercial herbal preparation. Afr. J. Biotechnol, 2003, 2, 307–311.

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How an African-made dietary supplement promises to revolutionize medical treatment.

Nnaji, M. How an African-made dietary supplement promises to revolutionize medical treatment. The frican Courier (Germany). https://www.theafricancourier.de/africa/

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Drug Dictionary of the National Cancer Institute, USA

An herbal-based nutritional supplement containing the leaf sheaths of the plant Sorghum bicolor, with potential antioxidant, anti-inflammatory, chemopreventive and immunomodulating activities

Drug Dictionary of the National Cancer

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Jobelyn® ameliorates neurological deficits in rats with ischemic stroke through inhibition of release of pro-inflammatory cytokines and NF-ĸB signaling pathway

Umukoro, S.; Oghwere, E.E.; Ben-Azu, B.; Owoeye, O.; Ajayi, A.M.; Omorogbe, O.; Okubena, O. Jobelyn® ameliorates neurological deficits in rats with ischemic stroke through inhibition of release of pro-inflammatory cytokines and NF-ĸB signaling pathway Pathophysiology 2018, 26, 77-88.

 

West African Sorghum bicolor leaf sheaths have anti-inflammatory and immune-modulating properties in vitro.

Benson, K.F.; Beaman, J.L.; Ou, B.; Okubena, A.; Okubena, O.; Jensen G.S. West African Sorghum bicolor leaf sheaths have anti-inflammatory and immune-modulating properties in vitro. Journal of Medicinal Foods 2013, 16, 230–238.

 

Jobelyn® ameliorates neurological deficits in rats with ischemic stroke through inhibition of release of pro-inflammatory cytokines and NF-ĸB signaling pathway 

Umukoro, S.; Oghwere, E.E.; Ben-Azu, B.; Owoeye, O.; Ajayi, A.M.; Omorogbe, O.; Okubena, O. Jobelyn® ameliorates neurological deficits in rats with ischemic stroke through inhibition of release of pro-inflammatory cytokines and NF-ĸB signaling pathway Pathophysiology 2018, 26, 77-88.

 

 Neuroprotective effect of Jobelyn® in the hippocampus of alcoholic rat is mediated in part by alterations in GFAP and NF protein expressions.

Oyinbo, C.A.; Dare, W.N.; Avwioro, O.G.; Igbigbi, P.S. Neuroprotective effect of Jobelyn® in the hippocampus of alcoholic rat is mediated in part by alterations in GFAP and NF protein expressions. Advances in Biological Research 2015, 9, 305-317.

 

Clinical efficacy of a West African Sorghum bicolor-based traditional herbal preparation Jobelyn shows increased hemoglobin and CD4+ T-lymphocyte counts in HIV-positive patients.

Ayuba, G.I.; Jensen, G.S.; Benson, K.F.; Okubena, A.M.; Okubena, O.  Clinical efficacy of a West African Sorghum bicolor-based traditional herbal preparation Jobelyn shows increased hemoglobin and CD4+ T-lymphocyte counts in HIV-positive patients.  J Altern Complement Med. 2014, 20, 53–56.

 

An open-label, randomized, parallel-group comparative study of the efficacy of Sorghum bicolor extract in preoperative anemia.

Tayo ,  A.O.;  Dosunmu, O.;  Akinola  1 ,  I.O.; Adewunmi, A.;  Oloyede , O.A.; Akinbami,  A.A.; Osikomaiya , B.I.; Makanjuola, S.B.L. An open-label, randomized, parallel-group comparative study of the efficacy of Sorghum bicolor extract in preoperative anemia. Nutrition. 2007, 33, 113–117.

 

Jobelyn® exhibited anti-inflammatory, antioxidant, and membrane-stabilizing activities in experimental models,

Umukoro, S.; Oluwole, O.G.;  Eduviere, A.T.;  Omogbiya,  A.;   Ajayi,  A.M. Jobelyn® exhibited anti-inflammatory, antioxidant, and membrane-stabilizing activities in experimental models, J. Basic Clin. Physiol. Pharmacol. 2015, 26, 501–508.

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Jobelyn® attenuates inflammatory responses and neurobehavioural deficits associated with complete Freund-adjuvant-induced arthritis in mice

Omorogbe, O.; Ajayi, A.M.; Ben-Azu, B.; Oghwere, E.E.;  Adebesin, A.;  Aderibigbe, A.O.; Okubena, O.; Umukoro, S. Jobelyn® attenuates inflammatory responses and neurobehavioural deficits associated with complete Freund-adjuvant-induced arthritis in mice. & Pharmacother. 2018, 98, 585–593.

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Jobelyn®supplement lowered neuronal degeneration: significance of altered p53 and ɤ-Enolase protein expressions in prefrontal cortex of rat exposed to ethanol.

Oyinbo, C.A.; Igbigbi, P.S.; Avwioro, O.G. Jobelyn®supplement lowered neuronal degeneration: significance of altered p53 and ɤ-Enolase protein expressions in prefrontal cortex of rat exposed to ethanol. Annals of Neurosciences 2016, 23, 139–148.

 

Antioxidant property of Jobelyn® as the possible mechanism underlying its anti-amnesic effect in rodents

Umukoro, S.; Ugbomah, A.; Aderibigbe, A.; Omogbiya, A. Antioxidant property of Jobelyn® as the possible mechanism underlying its anti-amnesic effect in rodents. Basic and Clinical Neurosci. 2013, 4, 42-49.

 

Jobelyn® extends the life span and improves motor function in Drosophila melanogaster exposed to lipopolysaccharide via augmentation of antioxidant status.

John, R.; Abolaji, A.O.; Adedara, A.O.; Ajayi, A.M.; Aderibigbe, A.O.; Umukoro, S. Jobelyn® extends the life span and improves motor function in Drosophila melanogaster exposed to lipopolysaccharide via augmentation of antioxidant status. Metabolic Brain Disease 2022, 37, 1031-1040.

 

 Newly isolated compounds  from West African Sorghum bicolor leaf sheaths Jobelyn® show potential in cancer immunosurveillance.

Makanjuola, S.B.L.;   Dosunmu,  D.;   Ajonuma, L.;   Ogundaini,  A.; Okubena, O. Newly isolated compounds                from West African Sorghum bicolor leaf sheaths Jobelyn® show potential in cancer immunosurveillance. J. Cancer Res. & Ther. 2016,  4, 31-37.

 

Jobelyn, a sorghum-based nutritional supplement attenuates unpredictable chronic mild stress-induced memory deficits in mice.

Umukoro, S.; Omorogbe, O.; Aluko, O.M.; Eduviere, T.A.; Owoeye, O.; Oluwole, O.G. Jobelyn, a sorghum-based nutritional supplement attenuates unpredictable chronic mild stress-induced memory deficits in mice. Journal of Behavioral and Brain Sci. 2015, 5, 586-597.

 

Antidepressant-like property of Jobelyn® an African unique herbal formulation in mice.

Umukoro, S.; Eduviere, A.T.; Aladeokin, A.C.; Olugbemide, A.  Antidepressant-like property of Jobelyn® an African unique herbal formulation in mice. Drug Res. 2014, 64, 146-150.

 

New Highly Stable Dimeric 3-Deoxyanthocyanidin Pigments from Sorghum bicolor Leaf Sheath

Bhimalingeswarappa Geera, Leonnard O. Ojwang, and Joseph M. Awika …….New Highly Stable Dimeric 3-Deoxyanthocyanidin Pigments from Sorghum bicolor Leaf Sheath……..Journal of Food Science _ Vol. 77, Nr. 5, 2012 doi: 10.1111/j.1750-3841.2012.02668.x…………………..

 

Jobelyn pretreatment ameliorates symptoms of psychosis in experimental models

Itivere Adrian Omogbiya, Adegbuyi Oladele Aderibigbe and Adewale Ganiyu Bakre Jobelyn pretreatment ameliorates symptoms of psychosis in experimental models DOI 10.1515/jbcpp-2012-0073 J Basic Clin Physiol Pharmacol 2013

 

Thermal stability of 3-deoxyanthocyanidin pigments 

Thermal stability of 3-deoxyanthocyanidin pigments Liyi Yang , Linda Dykes , Joseph M. Awika Journal of Food Chemistry http://dx.doi.org/10.1016/j.foodchem.2014.03.105

 

Toxicological Profiles of Commercial Herbal Preparation, Jobelyn®

Toxicological Profiles of Commercial Herbal Preparation, Jobelyn® nternational Journal of Health Research, December 2009; 2(4): 369-374 © Poracom Academic Publishers. All rights reserved. Available at http://www.ijhr.orgR

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The short time effect of extract of Sorghum bicolor (Jobelyn) on the haematological parameters of Patients with Sickle Cell Anemia.

Dosunmu A. O. et al., Journal Of Harmonized Research in Medical & Health Sci.3(4), 2016, 3(4),296-302The short time effect of extract of Sorghum bicolor (Jobelyn) on the haematological parameters of Patients with Sickle Cell Anemia.

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Jobelyn® improves motor dysfunctions induced by haloperidol in mice via neuroprotective mechanisms relating to modulation of cAMP response-element binding protein and mitogen-activated protein kinase  

Umukoro, S., Ajayi, A.M., Ben-Azu, B. et al. Jobelyn® improves motor dysfunctions induced by haloperidol in mice via neuroprotective mechanisms relating to modulation of cAMP response-element binding protein and mitogen-activated protein kinase. Metab Brain Dis 38, 2269–2280 (2023). https://doi.org/10.1007/s11011-023-01253-z

 

Hepatoprotective and antioxidant activities of Hepacare®, a herbal formulation against carbon tetrachloride-induced liver injury.

Ishola IO, Akinyede AA, Robert AK, Omilabu SA. Hepatoprotective and antioxidant activities of Hepacare®, a herbal formulation against carbon tetrachloride-induced liver injury. Drug Res (Stuttg). 2015 Jan;65(1):30-9. doi: 10.1055/s-0034-1371829. Epub 2014 Apr 7. PMID: 24710964.

 

Haematopoietic induction and hepatic protective roles of Hepacare® in CCl4-induced hepatic damaged rats

Haematopoietic induction and hepatic protective roles of Hepacare® in CCl4-induced hepatic damaged rats Abiodun Humphrey Adebayo1 & Omolara Faith Yakubu1 & Oluwatobi Samuel Adegbite 1 & Olajuwon Okubena2Haematopoietic induction and hepatic protective roles of Hepacare® in CCl4-induced hepatic damaged rats

 

Evaluation of antimalarial and biochemical profiles of Abaleria Plasmodium berghei-infected mice

Abiodun Humphrey Adebayo and Omolara Faith Yakubu and Jacob O. Popoola and L. David and Gloria Nwabugwu Okenze and Amarachi Grace Agbafor and Olajuwon Okubena

Evaluation of antimalarial and biochemical profiles of Abaleria Plasmodium berghei-infected mice

 

Antimicrobial and Toxicity Studies on Holisa Herbal Formulation

Adebayo AH, Yakubu OF, Ezekiel-Hart ES, Okubena O. Antimicrobial and Toxicity Studies on Holisa Herbal Formulation. Trop J Nat Prod Res. 2021; 5(5):983-987. http://www.doi.org/10.26538/tjnpr/v5i5.30

https://www.tjnpr.org/viewarticle.aspx?articleid=1583

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TABLE OF PUBLISHED RESEARCH STUDIES FOR JOBELYN

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Sub-acute toxicological effects of Jobelyn® on pregnant albino rats

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1. Adebayo, A.H.; Yakubu, O.F.; Egbung, G.E.; Williams, O.I.; Okubena, O. Sub-acute toxicological effects of Jobelyn® on pregnant albino rats American Institute of Physics 2018, 1954:030018 doi.org/10.1063/1.5033398.

​

The West African Sorghum bicolor leaf sheath extract Jobelyn® and its diverse therapeutic potentials

​

2. Okubena, O.; Makanjuola, S.; Ajonuma, L.C.; Dosunmu, A.; Umukoro, S.; Erah, P.O. The West African Sorghum bicolor leaf sheath extract Jobelyn® and its diverse therapeutic potentials. MOJ Drug Design & Development Therapy 2018, 2, 1-10. DOI: 10.15406/mojddt.2018.02.00025.

​

Apigenin and apigeninidin isolates from the Sorghum bicolor leaf targets inflammation via cyclooxygenase‐2 and prostaglandin‐E2 blockade.

​

3. Makanjuola, S.B.L.; Ogundaini, A.O.; Ajonuma, L.C.; Dosunmu, A. Apigenin and apigeninidin isolates from the Sorghum bicolor leaf targets inflammation via cyclooxygenase‐2 and prostaglandin‐E2 blockade. Clin Transplant. 2018, 21, 1487‐

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The influence of African herbal formular on the haematological parameters of trypanosome infected rats.

​

4. Okochi VI, Okpuzor J, Okubena MO, Awoyemi AK. The influence of African herbal formular on the haematological parameters of trypanosome infected rats. J. Biotech. 2003, 2, 312–316.

​

Response of trypanosoma brucei-induced anaemia to a commercial herbal preparation.

​

5. Erah, P.O.; Asonye, C.C, Okhamafe, A.O. Response of trypanosoma brucei-induced anaemia to a commercial herbal preparation. Afr. J. Biotechnol, 2003, 2, 307–311.

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6. Nnaji, M. How an African-made dietary supplement promises to revolutionize medical treatment. The African Courier (Germany). https://www.theafricancourier.de/africa/

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7. Drug Dictionary of the National Cancer Institute, USA (https://www.cancer.gov/publications/dictionaries/cancer-drug/def/sorghum-bicolor-supplement

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8. Umukoro, S.; Oghwere, E.E.; Ben-Azu, B.; Owoeye, O.; Ajayi, A.M.; Omorogbe, O.; Okubena, O. Jobelyn® ameliorates neurological deficits in rats with ischemic stroke through inhibition of release of pro-inflammatory cytokines and NF-ĸB signaling pathway Pathophysiology 2018, 26, 77-88.

 

9. Benson, K.F.; Beaman, J.L.; Ou, B.; Okubena, A.; Okubena, O.; Jensen G.S. West African Sorghum bicolor leaf sheaths have anti-inflammatory and immune-modulating properties in vitro. Journal of Medicinal Foods 2013, 16, 230–238.

 

10. Umukoro, S.; Oghwere, E.E.; Ben-Azu, B.; Owoeye, O.; Ajayi, A.M.; Omorogbe, O.; Okubena, O. Jobelyn® ameliorates neurological deficits in rats with ischemic stroke through inhibition of release of pro-inflammatory cytokines and NF-ĸB signaling pathway Pathophysiology 2018, 26, 77-88.

 

11. Oyinbo, C.A.; Dare, W.N.; Avwioro, O.G.; Igbigbi, P.S. Neuroprotective effect of Jobelyn® in the hippocampus of alcoholic rat is mediated in part by alterations in GFAP and NF protein expressions. Advances in Biological Research 2015, 9, 305-317.

 

12. Ayuba, G.I.; Jensen, G.S.; Benson, K.F.; Okubena, A.M.; Okubena, O.  Clinical efficacy of a West African Sorghum bicolor-based traditional herbal preparation Jobelyn shows increased hemoglobin and CD4+ T-lymphocyte counts in HIV-positive patients.  J Altern Complement Med. 2014, 20, 53–56.

 

13. Tayo ,  A.O.;  Dosunmu, O.;  Akinola  1 ,  I.O.; Adewunmi, A.;  Oloyede , O.A.; Akinbami,  A.A.; Osikomaiya , B.I.; Makanjuola, S.B.L. An open-label, randomized, parallel-group comparative study of the efficacy of Sorghum bicolor extract in preoperative anemia. Nutrition. 2007, 33, 113–117.

 

14. Umukoro, S.; Oluwole, O.G.;  Eduviere, A.T.;  Omogbiya,  A.;   Ajayi,  A.M. Jobelyn® exhibited anti-inflammatory, antioxidant, and membrane-stabilizing activities in experimental models, J. Basic Clin. Physiol. Pharmacol. 2015, 26, 501–508.

 

15. Omorogbe, O.; Ajayi, A.M.; Ben-Azu, B.; Oghwere, E.E.;  Adebesin, A.;  Aderibigbe, A.O.; Okubena, O.; Umukoro, S. Jobelyn® attenuates inflammatory responses and neurobehavioural deficits associated with complete Freund-adjuvant-induced arthritis in mice. & Pharmacother. 2018, 98, 585–593.

 

16. Oyinbo, C.A.; Igbigbi, P.S.; Avwioro, O.G. Jobelyn®supplement lowered neuronal degeneration: significance of altered p53 and ɤ-Enolase protein expressions in prefrontal cortex of rat exposed to ethanol. Annals of Neurosciences 2016, 23, 139–148.

 

17. Umukoro, S.; Ugbomah, A.; Aderibigbe, A.; Omogbiya, A. Antioxidant property of Jobelyn® as the possible mechanism underlying its anti-amnesic effect in rodents. Basic and Clinical Neurosci. 2013, 4, 42-49.

 

18. John, R.; Abolaji, A.O.; Adedara, A.O.; Ajayi, A.M.; Aderibigbe, A.O.; Umukoro, S. Jobelyn® extends the life span and improves motor function in Drosophila melanogaster exposed to lipopolysaccharide via augmentation of antioxidant status. Metabolic Brain Disease 2022, 37, 1031-1040.

 

19. Makanjuola, S.B.L.;   Dosunmu,  D.;   Ajonuma, L.;   Ogundaini,  A.; Okubena, O. Newly isolated compounds                from West African Sorghum bicolor leaf sheaths Jobelyn® show potential in cancer immunosurveillance. J. Cancer Res. & Ther. 2016,  4, 31-37.

 

20. Umukoro, S.; Omorogbe, O.; Aluko, O.M.; Eduviere, T.A.; Owoeye, O.; Oluwole, O.G. Jobelyn, a sorghum-based nutritional supplement attenuates unpredictable chronic mild stress-induced memory deficits in mice. Journal of Behavioral and Brain Sci. 2015, 5, 586-597.

 

27.Umukoro, S.; Eduviere, A.T.; Aladeokin, A.C.; Olugbemide, A.  Antidepressant-like property of Jobelyn® an African unique herbal formulation in mice. Drug Res. 2014, 64, 146-150.

 

28.Bhimalingeswarappa Geera, Leonnard O. Ojwang, and Joseph M. Awika …….New Highly Stable Dimeric 3-Deoxyanthocyanidin Pigments from Sorghum bicolor Leaf Sheath……..Journal of Food Science _ Vol. 77, Nr. 5, 2012 doi: 10.1111/j.1750-3841.2012.02668.x…………………..

 

29.Itivere Adrian Omogbiya, Adegbuyi Oladele Aderibigbe and Adewale Ganiyu Bakre Jobelyn pretreatment ameliorates symptoms of psychosis in experimental models DOI 10.1515/jbcpp-2012-0073 J Basic Clin Physiol Pharmacol 2013

 

30. Thermal stability of 3-deoxyanthocyanidin pigments Liyi Yang , Linda Dykes , Joseph M. Awika Journal of Food Chemistry http://dx.doi.org/10.1016/j.foodchem.2014.03.105

 

31. Toxicological Profiles of Commercial Herbal Preparation, Jobelyn® nternational Journal of Health Research, December 2009; 2(4): 369-374 © Poracom Academic Publishers. All rights reserved. Available at http://www.ijhr.orgR

 

32. Dosunmu A. O. et al., Journal Of Harmonized Research in Medical & Health Sci.3(4), 2016, 3(4),296-302The short time effect of extract of Sorghum bicolor (Jobelyn) on the haematological parameters of Patients with Sickle Cell Anemia.

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Dosunmu A. O. et al., Journal Of Harmonized Research in Medical & Health Sci.3(4), 2016, 3(4),296-302The short time effect of extract of Sorghum bicolor (Jobelyn) on the haematological parameters of Patients with Sickle Cell Anemia.

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